First-in-class treatment-with a mechanism
of action that lifts upper eyelids

Upneeq is the only FDA-approved prescription eyedrop for acquired ptosis (low-lying lids) that lifts your upper eyelids to open your eyes. The once daily eyedrop temporarily lifts the muscle of the upper eyelid, causing the eyes to open wider. This results in younger-looking eyes and an overall more rejuvenated appearance.

Upneeq is designed to treat acquired ptosis, the most common cause of droopy eyelids.

Millions of adults over the age of 40 suffer from some degree of acquired ptosis. The skin loses structural proteins (elastin and collagen) that provide elasticity as the skin gets older. Elasticity is the ability of the skin to bounce back into place. Loss of elasticity and the constant pull of gravity causes the upper eyelid to droop down over the eye. Acquired ptosis is primarily a cosmetic concern. However, drooping eyelids can also impair vision.



Upneeq is a prescription eyedrop. One eye drop is inserted into each eye once a day.

Upneeq’s active ingredient consists of a 0.1 percent oxymetazoline hydrochloride ophthalmic solution. Oxymetazoline is found in other medications, like nasal decongestant spray. With Upneeq, oxymetazoline causes the upper eyelid muscle to contract (tighten up). This causes a subtle lifting effect and opens the eyes wider.

Upneeq’s lifting effect is temporary. Visible improvement is typically seen within 15 minutes of application. Results can last up to six hours.


Upneeq is designed for men and women suffering from acquired ptosis (droopy eyelids caused by aging.) The daily eyedrop provides moderate improvement. It is ideal for individuals who want younger-looking eyes without surgical intervention.

Upneeq may interfere with certain medications, especially those that affect blood pressure and amine metabolism. Be sure to disclose medication use and medical history to your doctor.


Upneeq is FDA-approved and clinically proven to be safe and effective. Side effects are rare. However, in a small percentage of patients, Upneeq may cause eye inflammation, redness, dryness, blurred vision, or headache. These side effects are temporary.

Before and After

Drooping eyelids before Upneeq
Upneeq Can Play A Role in Enhancing Patient Outcomes and Practice Objectives

Clinical studies prove Upneeq to be safe and effective at improving the appearance of the upper eyelid and scope of vision.

Nearly 90 percent of patients demonstrated a visible improvement. 74 percent of these patients demonstrated great results, with 50 percent or more improvement to their upper eyelids.

On average, patients saw a 1mm lift in their upper eyelid.

Most patients saw a noticeable lift in their upper eyelids within 15 minutes of applying the drops. Some patients saw improvement in as little as five minutes.